The Best Comfort Food Casserole with Buttermilk Biscuits and Ground Beef.
This hearty Beef and Biscuit Casserole is the perfect family dinner for busy weeknights.
Featuring a creamy, savory ground beef filling topped with fluffy homemade buttermilk biscuits, this comforting casserole brings together classic flavors in one easy-to-make dish.
With rich ingredients like cream cheese, cream of mushroom soup, and catsup, this casserole is flavorful, satisfying, and sure to be a crowd-pleaser.
Whether you're looking for an easy ground beef casserole or a homestyle dinner idea, this baked dish is a go-to for comfort food lovers.
Serve it hot straight from the oven—perfect for weeknight dinners, potlucks, or cozy weekend meals.
1½ lbs. ground beef (hamburger)
1 batch unbaked buttermilk biscuits or use refrigerated biscuit dough
1 can (10.5 oz) cream of mushroom soup
½ cup onion, chopped
4 oz. cream cheese
¼ cup milk
1 tsp. salt
½ cup catsup (or ketchup)
1. Cook the Beef Mixture
In a skillet over medium heat, brown the ground beef and chopped onions until fully cooked. Drain excess grease.
2. Mix the Filling
In a large bowl, combine the cooked beef mixture with cream cheese, milk, cream of mushroom soup, salt, and catsup. Stir until smooth and well mixed.
3. Bake the Base Layer
Spread the meat mixture evenly into a lightly buttered 9x13-inch baking dish. Bake in a preheated oven at 375°F (190°C) for 15 minutes.
4. Add the Biscuits
Carefully remove the dish from the oven and place unbaked buttermilk biscuits on top of the meat mixture. Leave space between each biscuit to allow them to rise.
5. Finish Baking
Return the casserole to the oven and bake for an additional 20 minutes, or until the biscuits are golden brown and fully cooked through. Baking time may vary depending on the size and thickness of your biscuits.
🛒 Choosing Ingredients
✔ Ground Beef – 80/20 for flavor, 90/10 for leaner option
✔ Onion – Finely chopped for a rich, aromatic base
✔ Garlic – Optional, but adds depth and savoriness
✔ Cream of Mushroom or Tomato Soup – Traditional base for creaminess
✔ Cream Cheese or Sour Cream – For extra richness and tang
✔ Catsup – Adds subtle sweetness and umami
✔ Biscuits – Homemade buttermilk biscuits or pre-made dough
✔ Optional Veggies – Peas, carrots, corn, or green beans for balance
✔ Seasonings – Salt, black pepper, paprika, thyme, Worcestershire sauce
👩🍳 Preparation
✔ Brown Beef First – Let it develop a deep color before adding other ingredients
✔ Drain Fat – Prevents greasy texture in the final bake
✔ Mix Wet Ingredients Separately – Combine soups, cream cheese, and seasonings before adding to beef
✔ Pre-Bake Biscuits (Optional) – Bake halfway if you want extra fluff and crispness
✔ Use an Oven-Safe Skillet – Makes it easy to go from stovetop to oven
🔥 Cooking Techniques
✔ Layer Evenly – Spread beef mixture in dish before adding biscuit topping
✔ Cover, Then Uncover – Bake covered to cook through, uncover to brown the biscuits
✔ Watch the Biscuits – Ensure tops are golden and bottoms are baked through
✔ Add Cheese on Top (Optional) – A sprinkle before the final bake adds melty richness
🍳 Balancing Flavors
✔ Savory + Sweet – Catsup and onions bring sweetness; balance with salt and herbs
✔ Add Depth – Worcestershire sauce or a splash of broth enhances umami
✔ Texture Matters – Biscuits should contrast with creamy beef layer
✔ Herby Finish – Top with fresh parsley or chives for brightness
📦 Storage
✔ Leftovers Keep Well – Store in an airtight container up to 3–4 days
✔ Freezer-Friendly – Wrap tightly and freeze up to 2 months
✔ Reheat Gently – Warm in oven or microwave; cover with foil to avoid drying
✔ Refresh with Broth – Add a splash of broth or milk when reheating to revive creaminess
🍽 Serving
✔ Serve Hot – Straight from the oven for best texture
✔ Pair With – A light salad or pickled veggies for contrast
✔ Rustic Presentation – Serve in the baking dish family-style
✔ Ideal For – Cozy weeknights, potlucks, or hearty weekend meals